[HTML][HTML] A new function for the C-terminal zinc finger of the glucocorticoid receptor: repression of RelA transactivation
J Liden, F Delaunay, I Rafter, JÅ Gustafsson… - Journal of Biological …, 1997 - ASBMB
Glucocorticoids inhibit NF-κB signaling by interfering with the NF-κB transcription factor
RelA. Previous studies have identified the DNA-binding domain (DBD) in the glucocorticoid
receptor (GR) as the major region responsible for this repressive activity. Using GR mutants
with chimeric DBDs the repressive function was found to be located in the C-terminal zinc
finger. As predicted from these results the mineralocorticoid receptor that contains a C-
terminal zinc finger identical to that of the GR was also able to repress RelA-dependent …
RelA. Previous studies have identified the DNA-binding domain (DBD) in the glucocorticoid
receptor (GR) as the major region responsible for this repressive activity. Using GR mutants
with chimeric DBDs the repressive function was found to be located in the C-terminal zinc
finger. As predicted from these results the mineralocorticoid receptor that contains a C-
terminal zinc finger identical to that of the GR was also able to repress RelA-dependent …