Studies of inflammatory mediators have established the tumor micro-environment as a driver
of oncogenesis. This inflammatory milieu often precedes cancer, however recent data also
point to the ability of oncogenic changes to induce inflammatory responses that are later
harnessed by the tumor to survive and proliferate. In this review, we propose that the IDH1
mutation, present in the majority of low-grade gliomas (LGGs), initiates an inflammatory
cascade that is ultimately hijacked by the tumor. Glioma infiltrating macrophages and …