Genetically mast-cell-deficient W/Wv and Sl/Sld mice. Their value for the analysis of the roles of mast cells in biologic responses in vivo.

SJ Galli, Y Kitamura - The American journal of pathology, 1987 - ncbi.nlm.nih.gov
SJ Galli, Y Kitamura
The American journal of pathology, 1987ncbi.nlm.nih.gov
Biologic Features A double dose ofmutant alleles at either the Wor SI locus ofthe mouse
produces the pleiotropic effects of macrocytic anemia, sterility, and lack ofhair pigmentation."
2 Kitamura and his colleagues foundthat W/WV and Si/Sid mice also express a
profounddeficiency in mast cells. 34 Table 1 summarizes some of the characteristics of
W/Wv and Sl/Sid mice, with particular emphasis on those features with a bearing on the mast
cell deficiency. One of the most important distinctions between W/Wv and Si/Sldmice is the …
Biologic Features A double dose ofmutant alleles at either the Wor SI locus ofthe mouse produces the pleiotropic effects of macrocytic anemia, sterility, and lack ofhair pigmentation." 2 Kitamura and his colleagues foundthat W/WV and Si/Sid mice also express a profounddeficiency in mast cells. 34 Table 1 summarizes some of the characteristics of W/Wv and Sl/Sid mice, with particular emphasis on those features with a bearing on the mast cell deficiency.
One of the most important distinctions between W/Wv and Si/Sldmice is the different susceptibility of their mast celldeficiency to repair by intravenous transplantation of genetically compatible bone marrow cells derived from mice with normal numbers of mast cells. The hematologic defects in W/Wvmice are thought to reflect an intrinsic defect in hematopoietic stem cells (CFU-S), 7, 8whereas transplantation studies
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