Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury

T Sawa, TL Yahr, M Ohara, K Kurahashi, MA Gropper… - Nature medicine, 1999 - nature.com
T Sawa, TL Yahr, M Ohara, K Kurahashi, MA Gropper, JP Wiener-Kronish, DW Frank
Nature medicine, 1999nature.com
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute
lung infections in critically ill individuals. Damage to the lung epithelium is associated with
the expression of toxins that are directly injected into eukaryotic cells through a type III-
mediated secretion and translocation mechanism. Here we show that the P. aeruginosa
homolog of the Yersinia V antigen, PcrV, is involved in the translocation of type III toxins.
Vaccination against PcrV ensured the survival of challenged mice and decreased lung …
Abstract
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute lung infections in critically ill individuals. Damage to the lung epithelium is associated with the expression of toxins that are directly injected into eukaryotic cells through a type III-mediated secretion and translocation mechanism. Here we show that the P. aeruginosa homolog of the Yersinia V antigen, PcrV, is involved in the translocation of type III toxins. Vaccination against PcrV ensured the survival of challenged mice and decreased lung inflammation and injury. Antibodies to PcrV inhibited the translocation of type III toxins.
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