Immunoproteasomes: structure, function, and antigen presentation

DA Ferrington, DS Gregerson - Progress in molecular biology and …, 2012 - Elsevier
Immunoproteasomes contain replacements for the three catalytic subunits of standard
proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that
lead to elevated production of immunoproteasomes. Immune system cells, especially
antigen-presenting cells, express a higher basal level of immunoproteasomes. A well-
described function of immunoproteasomes is to generate peptides with a hydrophobic C
terminus that can be processed to fit in the groove of MHC class I molecules. This display of …