[HTML][HTML] Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation

JH Jhamandas, V Goncharuk - Frontiers in endocrinology, 2013 - frontiersin.org
JH Jhamandas, V Goncharuk
Frontiers in endocrinology, 2013frontiersin.org
Neuropeptide FF (NPFF) is an octapeptide belonging to the RFamide family of peptides that
have been implicated in a wide variety of physiological functions in the brain including
central cardiovascular and neuroendocrine regulation. The effects of these peptides are
mediated via NPFF1 and NPFF2 receptors that are abundantly expressed in the rat and
human brain. Herein, we review evidence for the role of NPFF in central regulation of blood
pressure particularly within the brainstem and the hypothalamic paraventricular nucleus …
Neuropeptide FF (NPFF) is an octapeptide belonging to the RFamide family of peptides that have been implicated in a wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation. The effects of these peptides are mediated via NPFF1 and NPFF2 receptors that are abundantly expressed in the rat and human brain. Herein, we review evidence for the role of NPFF in central regulation of blood pressure particularly within the brainstem and the hypothalamic paraventricular nucleus (PVN). At a cellular level, NPFF demonstrates distinct responses in magnocellular and parvocellular neurons of the PVN, which regulate the secretion of neurohypophyseal hormones and sympathetic outflow, respectively. Finally, the presence of NPFF system in the human brain and its alterations within the hypertensive brain are discussed.
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