2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research

MM Slaughter, RF Miller - Science, 1981 - science.org
MM Slaughter, RF Miller
Science, 1981science.org
Information processing in the vertebrate retina occurs in two separate channels known as
ON and OFF channels. When intracellular electrophysiological recordings were obtained
from the perfused retina-eyecup preparation of the mudpuppy (Necturus maculosus), the
addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses
in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-
Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by …
Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mudpuppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.
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