[HTML][HTML] The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

M Abu-Farha, JP Lambert, AS Al-Madhoun… - Molecular & cellular …, 2008 - ASBMB
Very little is known about SET-and MYND-containing protein 2 (SMYD2), a member of the
SMYD protein family. However, the interest in better understanding the roles of SMYD2 has
grown because of recent reports indicating that SMYD2 methylates p53 and histone H3. In
this study, we present a combined proteomics and genomics study of SMYD2 designed to
elucidate its molecular roles. We report the cytosolic and nuclear interactome of SMYD2
using a combination of immunoprecipitation coupled with high throughput MS, chromatin …