Neural innervation of white adipose tissue and the control of lipolysis

TJ Bartness, Y Liu, YB Shrestha, V Ryu - Frontiers in neuroendocrinology, 2014 - Elsevier
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its
activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-
executed SNS–norepinephrine (NE)-mediated WAT lipolysis is dependent on β-
adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A
phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically
and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific …