[HTML][HTML] Genetics ignite focus on microglial inflammation in Alzheimer's disease
Molecular neurodegeneration, 2015•Springer
In the past five years, a series of large-scale genetic studies have revealed novel risk factors
for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the
role of immune processes in AD, specifically microglial function. In this review, we discuss
interpretation of genetic studies. We then focus upon six genes implicated by AD genetics
that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review
the literature regarding the biological functions of these six proteins and their putative role in …
for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the
role of immune processes in AD, specifically microglial function. In this review, we discuss
interpretation of genetic studies. We then focus upon six genes implicated by AD genetics
that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review
the literature regarding the biological functions of these six proteins and their putative role in …
Abstract
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
Springer