[HTML][HTML] C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid …
ME Benoit, MX Hernandez, ML Dinh… - Journal of Biological …, 2013 - ASBMB
Complement protein C1q is induced in the brain in response to a variety of neuronal injuries,
including Alzheimer disease (AD), and blocks fibrillar amyloid-β (fAβ) neurotoxicity in vitro.
Here, we show that C1q protects immature and mature primary neurons against fAβ toxicity,
and we report for the first time that C1q prevents toxicity induced by oligomeric forms of
amyloid-β (Aβ). Gene expression analysis reveals C1q-activated phosphorylated cAMP-
response element-binding protein and AP-1, two transcription factors associated with …
including Alzheimer disease (AD), and blocks fibrillar amyloid-β (fAβ) neurotoxicity in vitro.
Here, we show that C1q protects immature and mature primary neurons against fAβ toxicity,
and we report for the first time that C1q prevents toxicity induced by oligomeric forms of
amyloid-β (Aβ). Gene expression analysis reveals C1q-activated phosphorylated cAMP-
response element-binding protein and AP-1, two transcription factors associated with …