Insulin resistance is accompanied by hyperinsulinemia and activation of the renin-
angiotensin system, both of which are associated with hypertension. Because the kidney
plays a major role in the regulation of blood pressure, we studied the regulation of insulin
receptor expression in the kidney during states of insulin resistance. Using two rat models of
insulin resistance, Western blot analysis demonstrated a significant reduction in the
expression of insulin receptor subunits in the kidney compared to lean control rats …