Administration of a probiotic with peanut oral immunotherapy: a randomized trial

MLK Tang, AL Ponsonby, F Orsini, D Tey… - Journal of Allergy and …, 2015 - Elsevier
Background Coadministration of a bacterial adjuvant with oral immunotherapy (OIT) has
been suggested as a potential treatment for food allergy. Objective To evaluate a combined
therapy comprising a probiotic together with peanut OIT. Methods We performed a double-
blind, placebo-controlled randomized trial of the probiotic Lactobacillus rhamnosus CGMCC
1.3724 and peanut OIT (probiotic and peanut oral immunotherapy [PPOIT]) in children (1-10
years) with peanut allergy. The primary outcome was induction of sustained …