Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach
H Sasaki, T Oura, TR Spitzer, YB Chen, JC Madsen… - Human immunology, 2018 - Elsevier
Based upon observations in murine models, we have developed protocols to induce renal
allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-
human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved
to be extremely difficult in major histocompatibility complex (MHC)-mismatched primates,
with detectable chimerism typically disappearing within 30–60 days. Nevertheless, in MHC
mismatched NHP, long-term immunosuppression-free renal allograft survival has been …
allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-
human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved
to be extremely difficult in major histocompatibility complex (MHC)-mismatched primates,
with detectable chimerism typically disappearing within 30–60 days. Nevertheless, in MHC
mismatched NHP, long-term immunosuppression-free renal allograft survival has been …
