Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin
DR Nagarkar, JA Poposki, MR Comeau… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Airway epithelial cells are important regulators of innate and adaptive
immunity. Although mast cells are known to play a central role in manifestations of allergic
inflammation and are found in the epithelium in patients with TH2-related diseases, their role
is incompletely understood. OBJECTIVES: The objective of this study was to investigate the
role of airway epithelial cells in the production of TH2 cytokines in mast cells. METHODS:
Normal human bronchial epithelial (NHBE) cells were stimulated with TNF, IL-4, IFN-γ, IL …
immunity. Although mast cells are known to play a central role in manifestations of allergic
inflammation and are found in the epithelium in patients with TH2-related diseases, their role
is incompletely understood. OBJECTIVES: The objective of this study was to investigate the
role of airway epithelial cells in the production of TH2 cytokines in mast cells. METHODS:
Normal human bronchial epithelial (NHBE) cells were stimulated with TNF, IL-4, IFN-γ, IL …
