Baroreceptor nerve endings detect acute fluctuations in arterial pressure. We tested the hypothesis that members of the DEG/ENaC family of cation channels, which are responsible for touch sensation in Caenorhabditis elegans, may be components of the baroreceptor mechanosensor. We found the γ subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus. A functional role for DEG/ENaC members was suggested by blockade of baroreceptor nerve activity and baroreflex control of blood pressure by an amiloride analog that inhibits DEG/ENaC channels. These data suggest that ENaC subunits may be components of the baroreceptor mechanotransducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension.