Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis
Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell
proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways
have been proposed to regulate cell polarity and migration, including metastasis. In this
review, we discuss the possible roles of both β-catenin-dependent and-independent
signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family
GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and …
proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways
have been proposed to regulate cell polarity and migration, including metastasis. In this
review, we discuss the possible roles of both β-catenin-dependent and-independent
signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family
GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and …
Abstract
Wnt/β-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. β-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both β-catenin-dependent and-independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
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