[HTML][HTML] The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains
S Frese, WD Schubert, AC Findeis, T Marquardt… - Journal of Biological …, 2006 - ASBMB
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that
modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine
kinases or phosphorylated signaling intermediates. Two mammalian pathogens,
enteropathogenic Escherichia coli and vaccinia virus, exploit Nck as part of their infection
strategy. Conflicting data indicate potential differences in the recognition specificities of the
SH2 domains of the isoproteins Nck1 (Nckα) and Nck2 (Nckβ and Grb4). We have …
modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine
kinases or phosphorylated signaling intermediates. Two mammalian pathogens,
enteropathogenic Escherichia coli and vaccinia virus, exploit Nck as part of their infection
strategy. Conflicting data indicate potential differences in the recognition specificities of the
SH2 domains of the isoproteins Nck1 (Nckα) and Nck2 (Nckβ and Grb4). We have …
