Reciprocal regulation of HIF-1α and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia
L Yao, X Nie, S Shi, S Song, X Hao, S Li… - Prostaglandins & Other …, 2012 - Elsevier
15-Hydroxyeicosatetraenoic acid, a predominant metabolic product of arachidonic acid (AA)
catalyzed by 15-lipoxygenase (15-LO), plays an important role in hypoxic pulmonary arterial
hypertension (PAH). Hypoxia-inducible factor-1α (HIF-1α) as a critical oxygen-sensitive
transcriptional factor participates in many physiological and pathological processes
including PAH. Therefore, it is possible that there may be some connections between HIF-1α
and 15-LO/15-HETE in hypoxic pulmonary artery smooth muscle cells. Our results showed …
catalyzed by 15-lipoxygenase (15-LO), plays an important role in hypoxic pulmonary arterial
hypertension (PAH). Hypoxia-inducible factor-1α (HIF-1α) as a critical oxygen-sensitive
transcriptional factor participates in many physiological and pathological processes
including PAH. Therefore, it is possible that there may be some connections between HIF-1α
and 15-LO/15-HETE in hypoxic pulmonary artery smooth muscle cells. Our results showed …
