Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia …
M Pekarova, A Koudelka, H Kolarova… - Vascular …, 2015 - Elsevier
Pulmonary hypertension (PH), associated with imbalance in vasoactive mediators and
massive remodeling of pulmonary vasculature, represents a serious health complication.
Despite the progress in treatment, PH patients typically have poor prognoses with severely
affected quality of life. Asymmetric dimethyl arginine (ADMA), endogenous inhibitor of
endothelial nitric oxide synthase (eNOS), also represents one of the critical regulators of
pulmonary vascular functions. The present study describes a novel mechanism of ADMA …
massive remodeling of pulmonary vasculature, represents a serious health complication.
Despite the progress in treatment, PH patients typically have poor prognoses with severely
affected quality of life. Asymmetric dimethyl arginine (ADMA), endogenous inhibitor of
endothelial nitric oxide synthase (eNOS), also represents one of the critical regulators of
pulmonary vascular functions. The present study describes a novel mechanism of ADMA …
