Ras proteins: different signals from different locations
JF Hancock - Nature reviews Molecular cell biology, 2003 - nature.com
Nature reviews Molecular cell biology, 2003•nature.com
Ras signalling has classically been thought to occur exclusively at the inner surface of a
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact
dynamically with specific microdomains of the plasma membrane as well as with other
internal cell membranes. These different membrane microenvironments modulate Ras
signal output and highlight the complex interplay between Ras location and function.
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact
dynamically with specific microdomains of the plasma membrane as well as with other
internal cell membranes. These different membrane microenvironments modulate Ras
signal output and highlight the complex interplay between Ras location and function.
Abstract
Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
nature.com
