[HTML][HTML] Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48 (∗)
KI Hirano, SG Young, V Robert Jr, J Ng, E Sande… - Journal of Biological …, 1996 - ASBMB
A site-specific C to U editing reaction modifies nuclear apolipoprotein B100 (apoB100)
mRNA, producing apolipoprotein B48 in the mammalian small intestine. This reaction is
mediated by a multicomponent enzyme complex, which contains a catalytic subunit, Apobec-
1. We have used gene targeting to disrupt mouse apobec-1 in order to establish its requisite
importance in apoB mRNA editing and also, in view of its widespread tissue distribution in
rodents, as a preliminary indication of other potential roles. Both heterozygous (apobec-1+/-) …
mRNA, producing apolipoprotein B48 in the mammalian small intestine. This reaction is
mediated by a multicomponent enzyme complex, which contains a catalytic subunit, Apobec-
1. We have used gene targeting to disrupt mouse apobec-1 in order to establish its requisite
importance in apoB mRNA editing and also, in view of its widespread tissue distribution in
rodents, as a preliminary indication of other potential roles. Both heterozygous (apobec-1+/-) …
