[HTML][HTML] The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo [3, 2-b] carbazole is present in humans
E Wincent, N Amini, S Luecke, H Glatt… - Journal of biological …, 2009 - ASBMB
Dioxins and other polycyclic aromatic compounds formed during the combustion of waste
and fossil fuels represent a risk to human health, as well as to the well being of our
environment. Compounds of this nature exert carcinogenic and endocrine-disrupting effects
in experimental animals by binding to the orphan aryl hydrocarbon receptor (AhR).
Understanding the mechanism of action of these pollutants, as well as the physiological role
(s) of the AhR, requires identification of the endogenous ligand (s) of this receptor. We …
and fossil fuels represent a risk to human health, as well as to the well being of our
environment. Compounds of this nature exert carcinogenic and endocrine-disrupting effects
in experimental animals by binding to the orphan aryl hydrocarbon receptor (AhR).
Understanding the mechanism of action of these pollutants, as well as the physiological role
(s) of the AhR, requires identification of the endogenous ligand (s) of this receptor. We …
