Human aging and cancer: role of miRNA in tumor microenvironment
OA Sandiford, CA Moore, J Du, M Boulad… - Exosomes, Stem Cells …, 2018 - Springer
OA Sandiford, CA Moore, J Du, M Boulad, M Gergues, H Eltouky, P Rameshwar
Exosomes, Stem Cells and MicroRNA: Aging, Cancer and Age Related Disorders, 2018•SpringerHuman aging is an inevitable and complex phenomenon characterized by a progressive,
gradual degradation of physiological and cellular processes that leads from vulnerability to
death. Mammalian somatic cells display limited proliferative properties in vitro that results in
a process of permanent cell cycle arrest commonly known as senescence. Events leading to
cellular senescence are complex but may be due to the increase in tumor suppressor genes,
caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome …
gradual degradation of physiological and cellular processes that leads from vulnerability to
death. Mammalian somatic cells display limited proliferative properties in vitro that results in
a process of permanent cell cycle arrest commonly known as senescence. Events leading to
cellular senescence are complex but may be due to the increase in tumor suppressor genes,
caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome …
Abstract
Human aging is an inevitable and complex phenomenon characterized by a progressive, gradual degradation of physiological and cellular processes that leads from vulnerability to death. Mammalian somatic cells display limited proliferative properties in vitro that results in a process of permanent cell cycle arrest commonly known as senescence. Events leading to cellular senescence are complex but may be due to the increase in tumor suppressor genes, caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome of the cell, an important risk factor for the occurrence of cancer. Adults over the age of 65+ are vulnerable to age related diseases such as cancers but such changes may begin at middle age. MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging.
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