Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth
K Matsumoto, H Tajima, T Nakamura - Biochemical and biophysical …, 1991 - Elsevier
K Matsumoto, H Tajima, T Nakamura
Biochemical and biophysical research communications, 1991•ElsevierHepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary
culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes
in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml
HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors,
while it was inhibited by transforming growth factor-β1. Melanocytes expressed a single
class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 …
culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes
in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml
HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors,
while it was inhibited by transforming growth factor-β1. Melanocytes expressed a single
class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 …
Abstract
Hepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors, while it was inhibited by transforming growth factor-β1. Melanocytes expressed a single class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 receptors/cell. Thus, HGF is a potent mitogen for normal human epidermal melanocytes.
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