Estrogen receptor α gene polymorphisms and risk of myocardial infarction
SCE Schuit, HHS Oei, JCM Witteman, CHG van Kessel… - Jama, 2004 - jamanetwork.com
ContextThe role of estrogens in ischemic heart disease (IHD) is uncertain. Evidence
suggests that genetic variations in the estrogen receptor α (ESR1) gene may influence IHD
risk, but the role of common sequence variations in the ESR1 gene is unclear. ObjectiveTo
determine whether the ESR1 haplotype created by the c. 454-397T> C (PvuII) and c. 454-
351A> G (XbaI) polymorphisms is associated with myocardial infarction (MI) and IHD risk.
Design, Setting, and ParticipantsIn 2617 men and 3791 postmenopausal women from The …
suggests that genetic variations in the estrogen receptor α (ESR1) gene may influence IHD
risk, but the role of common sequence variations in the ESR1 gene is unclear. ObjectiveTo
determine whether the ESR1 haplotype created by the c. 454-397T> C (PvuII) and c. 454-
351A> G (XbaI) polymorphisms is associated with myocardial infarction (MI) and IHD risk.
Design, Setting, and ParticipantsIn 2617 men and 3791 postmenopausal women from The …