[HTML][HTML] The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function*♦
JP Etchegaray, X Yang, JP DeBruyne… - Journal of Biological …, 2006 - ASBMB
We examined the importance of histone methylation by the polycomb group proteins in the
mouse circadian clock mechanism. Endogenous EZH2, a polycomb group enzyme that
methylates lysine 27 on histone H3, co-immunoprecipitates with CLOCK and BMAL1
throughout the circadian cycle in liver nuclear extracts. Chromatin immunoprecipitation
revealed EZH2 binding and di-and trimethylation of H3K27 on both the Period 1 and Period
2 promoters. A role of EZH2 in cryptochrome-mediated transcriptional repression of the …
mouse circadian clock mechanism. Endogenous EZH2, a polycomb group enzyme that
methylates lysine 27 on histone H3, co-immunoprecipitates with CLOCK and BMAL1
throughout the circadian cycle in liver nuclear extracts. Chromatin immunoprecipitation
revealed EZH2 binding and di-and trimethylation of H3K27 on both the Period 1 and Period
2 promoters. A role of EZH2 in cryptochrome-mediated transcriptional repression of the …
