Nocturnal body core temperature falls in Parkinson's disease but not in multiple‐system atrophy
G Pierangeli, F Provini, P Maltoni… - … : official journal of the …, 2001 - Wiley Online Library
G Pierangeli, F Provini, P Maltoni, G Barletta, M Contin, E Lugaresi, P Montagna, P Cortelli
Movement disorders: official journal of the Movement Disorder Society, 2001•Wiley Online LibraryOBJECTIVE: To evaluate whether the circadian rhythm of body core temperature (CRT°) can
differentiate Multiple‐System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).
METHODS: We evaluated 14 patients with probable MSA, seven with IPD, and eight
controls. After a preliminary evaluation of cardiovascular autonomic function, rectal
temperature and sleep‐wake cycle were monitored continuously for 48 hours in a
temperature‐controlled room, at constant bed rest with controlled food intake and fixed light …
differentiate Multiple‐System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).
METHODS: We evaluated 14 patients with probable MSA, seven with IPD, and eight
controls. After a preliminary evaluation of cardiovascular autonomic function, rectal
temperature and sleep‐wake cycle were monitored continuously for 48 hours in a
temperature‐controlled room, at constant bed rest with controlled food intake and fixed light …
OBJECTIVE
To evaluate whether the circadian rhythm of body core temperature (CRT°) can differentiate Multiple‐System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).
METHODS
We evaluated 14 patients with probable MSA, seven with IPD, and eight controls. After a preliminary evaluation of cardiovascular autonomic function, rectal temperature and sleep‐wake cycle were monitored continuously for 48 hours in a temperature‐controlled room, at constant bed rest with controlled food intake and fixed light‐dark schedule.
RESULTS
MSA patients showed cardiovascular autonomic sympathetic and parasympathetic failure. IPD had normal cardiovascular autonomic function. A 24‐hour rhythm of body core temperature (BcT°) was present in all subjects. IPD had CRT° comparable to controls. In MSA the mesor was higher and mean BcT° of each hour was significantly higher from 11 p.m. to 7 a.m. The analysis of mean BcT° during the different sleep phases showed significantly higher values during both NREM (1–2, 3–4) and REM sleep stages in MSA.
CONCLUSIONS
The physiological nocturnal fall of BcT° is blunted in MSA patients mainly because BcT° did not decrease during sleep. This CRT° pattern is not justified by differences in sleep structure and may reflect an impairment of central sympathetic nervous system function. © 2001 Movement Disorder Society.
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