The limbic-hypothalamic-pituitary-adrenal axis in Huntington's disease
IJE Heuser, TN Chase, MM Mouradian - Biological psychiatry, 1991 - Elsevier
The functional integrity of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis was studied
in 10 patients with Huntington's disease (HD) and 10 age-and weight-matched control
subjects by measuring basal ACTH and cortisol secretion, analyzing the subjects' ACTH and
cortisol responses to corticotropin-releasing hormone (CRH) challenge, and by means of the
dexamethasone-suppression test (DST). Basal cortisol and ACTH levels were significantly
higher in patients with HD compared with controls. Following CRH administration, ACTH …
in 10 patients with Huntington's disease (HD) and 10 age-and weight-matched control
subjects by measuring basal ACTH and cortisol secretion, analyzing the subjects' ACTH and
cortisol responses to corticotropin-releasing hormone (CRH) challenge, and by means of the
dexamethasone-suppression test (DST). Basal cortisol and ACTH levels were significantly
higher in patients with HD compared with controls. Following CRH administration, ACTH …
