The circadian system orchestrates internal physiology on a daily schedule to promote
optimal health and maximize disease prevention. Chronic disruptions in circadian function
are associated with an increase in a variety of disease states including, heart disease, ulcers
and diabetes. With advanced age, the genes regulating circadian function at the cellular
level become disorganized and the ability of the brain clock to entrain to local time
diminishes. As a result, aged individuals exhibit a loss of temporal coordination among …