[HTML][HTML] Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
L Yin, Y Li, J Ren, H Kuwahara, D Kufe - Journal of Biological Chemistry, 2003 - ASBMB
The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed by most human
carcinomas. Certain insights are available regarding a role for MUC1 in intracellular
signaling; however, no precise function has been ascribed to this molecule. The present
results demonstrate that MUC1 expression is up-regulated by oxidative stress and that this
response is mediated by activation of MUC1 gene transcription. A role for MUC1 in the
oxidative stress response is supported by the demonstration that MUC1 expression is …
carcinomas. Certain insights are available regarding a role for MUC1 in intracellular
signaling; however, no precise function has been ascribed to this molecule. The present
results demonstrate that MUC1 expression is up-regulated by oxidative stress and that this
response is mediated by activation of MUC1 gene transcription. A role for MUC1 in the
oxidative stress response is supported by the demonstration that MUC1 expression is …
