Immunosuppressive activity of regulatory T cells (Tregs) is one of the mechanisms promoting
carcinogenesis. Intratumoral Tregs have some phenotypic and functional traits that lower the
efficiency of antitumor immune response, which makes them a good target for
immunotherapy. Several approaches to cancer immunotherapy are being developed along
this vector: deletion of tumor-infiltrating Tregs, inhibition of their homing to the tumor
microenvironment, and functional downregulation of Tregs. Studies of the past decade have …