Objective: Rheumatoid arthritis (RA) is characterized by symmetric peripheral polyarthritis,
inflammatory synovitis, and articular destruction. Statins, 3-hydroxy-3-methylglutaryl
coenzyme A-reductase inhibitors, mediate significant vascular risk reduction in patients with
coronary artery disease by promoting reduction in plasma levels of low-density-lipoprotein
cholesterol. Extensive in vitro data, experimental studies and more recently few clinical trials
have strongly suggested statins to possess an important role in RA mainly mediated by their …