Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease
Importance Recent large-scale genome-wide association studies have discovered several
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA
methylation in these AD loci contributes to the disease susceptibility remains unknown.
Objective To examine the association of brain DNA methylation in 28 reported AD loci with
AD pathologies. Design, Setting, and Participants Ongoing community-based clinical
pathological cohort studies of aging and dementia (the Religious Orders Study and the Rush …
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA
methylation in these AD loci contributes to the disease susceptibility remains unknown.
Objective To examine the association of brain DNA methylation in 28 reported AD loci with
AD pathologies. Design, Setting, and Participants Ongoing community-based clinical
pathological cohort studies of aging and dementia (the Religious Orders Study and the Rush …
