[HTML][HTML] Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells
ID (inhibitor of differentiation/DNA binding) proteins, frequently deregulated in advanced
human malignancies, can participate in multiple fundamental traits of cancer, such as block
of differentiation, increased proliferation, tissue invasiveness, and angiogenesis. We have
previously demonstrated that hypoxia decreases expression of neuronal marker genes in
neuroblastoma, but induces genes expressed in the neural crest, such as ID2. Because of its
involvement in normal neural crest development and its ability to inhibit proneuronal bHLH …
human malignancies, can participate in multiple fundamental traits of cancer, such as block
of differentiation, increased proliferation, tissue invasiveness, and angiogenesis. We have
previously demonstrated that hypoxia decreases expression of neuronal marker genes in
neuroblastoma, but induces genes expressed in the neural crest, such as ID2. Because of its
involvement in normal neural crest development and its ability to inhibit proneuronal bHLH …