Cardiac conduction system in congenitally corrected transposition of the great arteries and its clinical relevance

AE Baruteau, DJ Abrams, SY Ho… - Journal of the …, 2017 - Am Heart Assoc
AE Baruteau, DJ Abrams, SY Ho, JB Thambo, CJ McLeod, MJ Shah
Journal of the American Heart Association, 2017Am Heart Assoc
Congenitally corrected transposition of the great arteries (ccTGA) is a rare cardiac
malformation characterized by the combination of discordant atrioventricular and
ventriculoarterial connections. 1 The incidence has been reported to be around 1/33 000
live births, accounting for 0.05% of congenital heart malformations. 2 Although a familial
recurrence of heart defects in subjects with ccTGA has been reported, 3 the etiology of this
malformation is not currently known. 1, 4 The morphological right atrium is connected to the …
Congenitally corrected transposition of the great arteries (ccTGA) is a rare cardiac malformation characterized by the combination of discordant atrioventricular and ventriculoarterial connections. 1 The incidence has been reported to be around 1/33 000 live births, accounting for 0.05% of congenital heart malformations. 2 Although a familial recurrence of heart defects in subjects with ccTGA has been reported, 3 the etiology of this malformation is not currently known. 1, 4
The morphological right atrium is connected to the morphological left ventricle across the mitral valve, with the left ventricle then connected to the pulmonary trunk; the morphological left atrium is connected to the morphological right ventricle across the tricuspid valve, with the morphological right ventricle connected to the aorta. Because of this “double discordance,” the systemic venous return is pumped
Am Heart Assoc