[HTML][HTML] Melanoma genetics and the development of rational therapeutics
Y Chudnovsky, PA Khavari… - The Journal of clinical …, 2005 - Am Soc Clin Investig
Y Chudnovsky, PA Khavari, AE Adams
The Journal of clinical investigation, 2005•Am Soc Clin InvestigMelanoma is a cancer of the neural crest–derived cells that provide pigmentation to skin and
other tissues. Over the past 4 decades, the incidence of melanoma has increased more
rapidly than that of any other malignancy in the United States. No current treatments
substantially enhance patient survival once metastasis has occurred. This review focuses on
recent insights into melanoma genetics and new therapeutic approaches being developed
based on these advances.
other tissues. Over the past 4 decades, the incidence of melanoma has increased more
rapidly than that of any other malignancy in the United States. No current treatments
substantially enhance patient survival once metastasis has occurred. This review focuses on
recent insights into melanoma genetics and new therapeutic approaches being developed
based on these advances.
Melanoma is a cancer of the neural crest–derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
The Journal of Clinical Investigation