Soluble CD200 in secretory phase endometriosis endometrial venules may explain endometriosis pathophysiology and provide a novel treatment target
DA Clark, JM Dmetrichuk, S Dhesy-Thind… - Journal of reproductive …, 2018 - Elsevier
Retrograde menstruation is common and in about 10% of women, endometrial tissues
implant at ectopic sites and grow as endometriosis (EM) deposits. To date, there has been
no marker to identify which patients have an endometrium that will generate deposits. Both
endometrial regulatory T cells (Tregs) and increased stromal cell indoleamine 2, 3-
dioxygenase (IDO) have been implicated, and may suppress rejection by peritoneal NK
cells, neutrophils, and cytotoxic macrophages. CD200 is a tolerance signaling molecule …
implant at ectopic sites and grow as endometriosis (EM) deposits. To date, there has been
no marker to identify which patients have an endometrium that will generate deposits. Both
endometrial regulatory T cells (Tregs) and increased stromal cell indoleamine 2, 3-
dioxygenase (IDO) have been implicated, and may suppress rejection by peritoneal NK
cells, neutrophils, and cytotoxic macrophages. CD200 is a tolerance signaling molecule …