Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma
J Yuan, A Takahashi, N Masumori, K Uchida… - Urology, 2005 - Elsevier
OBJECTIVES: To examine whether peroxisome proliferator-activated receptor gamma
(PPARγ) is expressed in human renal cell carcinoma (RCC) cells, and whether activation of
PPARγ by its ligands can have multiple antitumor effects on human RCC cells in vitro.
METHODS: We examined the expression of PPARγ in four human RCC cell lines by reverse
transcriptase-polymerase chain reaction and immunocytochemical staining. The effects of
two PPARγ ligands, pioglitazone and 15-deoxy-Δ12, 14-prostaglandin J2, on cell …
(PPARγ) is expressed in human renal cell carcinoma (RCC) cells, and whether activation of
PPARγ by its ligands can have multiple antitumor effects on human RCC cells in vitro.
METHODS: We examined the expression of PPARγ in four human RCC cell lines by reverse
transcriptase-polymerase chain reaction and immunocytochemical staining. The effects of
two PPARγ ligands, pioglitazone and 15-deoxy-Δ12, 14-prostaglandin J2, on cell …