Metabolic syndrome and type 2 diabetes mellitus are associated with an increased number
of macrophage cells that infiltrate white adipose tissue (WAT). Previously, we demonstrated
that the treatment of subjects with impaired glucose tolerance (IGT) with the peroxisome
proliferator-activated receptor γ (PPARγ) agonist pioglitazone resulted in a decrease in
macrophage number in adipose tissue. Here, adipose tissue samples from IGT subjects
treated with pioglitazone were examined for apoptosis with terminal deoxynucleotidyl …