[HTML][HTML] The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation
SS Khurana, TE Riehl, BD Moore, M Fassan… - Journal of Biological …, 2013 - ASBMB
The stem cell in the isthmus of gastric units continually replenishes the epithelium. Atrophy
of acid-secreting parietal cells (PCs) frequently occurs during infection with Helicobacter
pylori, predisposing patients to cancer. Atrophy causes increased proliferation of stem cells,
yet little is known about how this process is regulated. Here we show that CD44 labels a
population of small, undifferentiated cells in the gastric unit isthmus where stem cells are
known to reside. Loss of CD44 in vivo results in decreased proliferation of the gastric …
of acid-secreting parietal cells (PCs) frequently occurs during infection with Helicobacter
pylori, predisposing patients to cancer. Atrophy causes increased proliferation of stem cells,
yet little is known about how this process is regulated. Here we show that CD44 labels a
population of small, undifferentiated cells in the gastric unit isthmus where stem cells are
known to reside. Loss of CD44 in vivo results in decreased proliferation of the gastric …