Atrial fibrillation is associated with impaired atrial mitochondrial energetics and supercomplex formation in adults with type 2 diabetes
GN Kanaan, DA Patten, CJ Redpath… - Canadian Journal of …, 2019 - Elsevier
Objectives Type 2 diabetes mellitus is a chronic progressive disease that is associated with
increased risk for cardiovascular diseases and with impaired mitochondrial metabolism in
cardiac and skeletal muscles. Atrial fibrillation (AF) is the most common sustained cardiac
arrhythmia and is associated with significant morbidity and mortality. Type 2 diabetes is also
one of the prevalent concomitant diseases in patients with AF. During AF, myocardial energy
demand is high due to electrical activity. To date, however, very little is known about the …
increased risk for cardiovascular diseases and with impaired mitochondrial metabolism in
cardiac and skeletal muscles. Atrial fibrillation (AF) is the most common sustained cardiac
arrhythmia and is associated with significant morbidity and mortality. Type 2 diabetes is also
one of the prevalent concomitant diseases in patients with AF. During AF, myocardial energy
demand is high due to electrical activity. To date, however, very little is known about the …