[HTML][HTML] CTLA-2 alpha is a potent inhibitor of angiogenesis in murine ocular tissue
K Maruyama, K Yoneda, S Sugita, Y Yamamoto… - Antioxidants, 2021 - mdpi.com
Cytotoxic T lymphocyte antigen-2 (CTLA-2) alpha has been reported to suppress the
activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we
assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue. To establish
models of corneal inflammation and experimental choroidal neovascularization (CNV), male
C57BL/6J mice (n= 5) underwent corneal suture placement or laser-induced CNV,
respectively. Mice were then injected with recombinant CTLA-2 alpha (1 µg) into the …
activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we
assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue. To establish
models of corneal inflammation and experimental choroidal neovascularization (CNV), male
C57BL/6J mice (n= 5) underwent corneal suture placement or laser-induced CNV,
respectively. Mice were then injected with recombinant CTLA-2 alpha (1 µg) into the …
[PDF][PDF] CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue. Antioxidants 2021, 10, 456
K Maruyama, K Yoneda, S Sugita, Y Yamamoto… - 2021 - stm.e4journal.com
Cytotoxic T lymphocyte antigen-2 (CTLA-2) alpha has been reported to suppress the
activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we
assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue. To establish
models of corneal inflammation and experimental choroidal neovascularization (CNV), male
C57BL/6J mice (n= 5) underwent corneal suture placement or laser-induced CNV,
respectively. Mice were then injected with recombinant CTLA-2 alpha (1 µg) into the …
activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we
assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue. To establish
models of corneal inflammation and experimental choroidal neovascularization (CNV), male
C57BL/6J mice (n= 5) underwent corneal suture placement or laser-induced CNV,
respectively. Mice were then injected with recombinant CTLA-2 alpha (1 µg) into the …