Background The mechanisms of ventilator-induced lung injury, an iatrogenic inflammatory
condition induced by mechanical ventilation, are not completely understood. Toll-like
receptor 4 (TLR4) signaling via the adaptor protein myeloid differentiation factor 88 (MyD88)
is proinflammatory and plays a critical role in host immune response to invading pathogen
and noninfectious tissue injury. The role of TLR4-MyD88 signaling in ventilator-induced lung
injury remains incompletely understood. Methods Mice were ventilated with low or high tidal …