A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse
JE Kerschner, W Hong, SR Taylor, JA Kerschner… - International journal of …, 2013 - Elsevier
OBJECTIVE: A novel mouse model with a specific genetic mutation in a G protein coupled
receptor (GPCR) encoded by the Oxgr1 gene results in a predisposition to spontaneous
otitis media with effusion. As a primary component of interest in OME, mucin expression was
examined in this model to assess expression as compared to wild type animals and
suitability as a murine model of OME. METHOD: Mutant (Oxgr1−/−) and wild-type (Oxgr1+/+)
mice between ages of 2 and 5 months were examined by otoscopy and auditory brainstem …
receptor (GPCR) encoded by the Oxgr1 gene results in a predisposition to spontaneous
otitis media with effusion. As a primary component of interest in OME, mucin expression was
examined in this model to assess expression as compared to wild type animals and
suitability as a murine model of OME. METHOD: Mutant (Oxgr1−/−) and wild-type (Oxgr1+/+)
mice between ages of 2 and 5 months were examined by otoscopy and auditory brainstem …
