[HTML][HTML] A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha [S]
The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key
regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-
kinase (PI4K) enzymes generate PI4P in different membrane compartments supporting
distinct cellular processes, many of which are crucial for the maintenance of cellular integrity
but also hijacked by intracellular pathogens. While type III PI4Ks have been targeted by
small molecular inhibitors, thus helping decipher their importance in cellular physiology, no …
regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-
kinase (PI4K) enzymes generate PI4P in different membrane compartments supporting
distinct cellular processes, many of which are crucial for the maintenance of cellular integrity
but also hijacked by intracellular pathogens. While type III PI4Ks have been targeted by
small molecular inhibitors, thus helping decipher their importance in cellular physiology, no …
