Regulated transport and local translation of mRNA in neurons are critical for modulating
synaptic strength, maintaining proper neural circuitry, and establishing long term memory.
Neuronal RNA granules are ribonucleoprotein particles that serve to transport mRNA along
microtubules and control local protein synthesis in response to synaptic activity. Studies
suggest that neuronal RNA granules share similar structures and functions with somatic P-
bodies. We recently reported that the Huntington disease protein huntingtin (Htt) associates …