The levels and composition of sphingolipids and related metabolites are altered in aging
and in common disorders such as diabetes and cancers, as well as in neurodegenerative,
cardiovascular, and respiratory diseases. Changes in sphingolipids have been implicated
as being an essential step in mitochondria-driven cell death. However, little is known about
the precise sphingolipid composition and modulation in mitochondria or related organelles.
Here, we used LC-MS/MS to analyze the presence of key components of the ceramide …