The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis
BH Wong, D Mei, GL Chua, DL Galam… - Journal of Biological …, 2022 - ASBMB
Pulmonary surfactant is a lipoprotein complex essential for lung function, and insufficiency or
altered surfactant composition is associated with major lung diseases, such as acute
respiratory distress syndromes, idiopathic pulmonary fibrosis, and chronic obstructive
pulmonary disease. Pulmonary surfactant is primarily composed of phosphatidylcholine
(PC) in complex with specialized surfactant proteins and secreted by alveolar type 2 (AT2)
cells. Surfactant homeostasis on the alveolar surface is balanced by the rates of synthesis …
altered surfactant composition is associated with major lung diseases, such as acute
respiratory distress syndromes, idiopathic pulmonary fibrosis, and chronic obstructive
pulmonary disease. Pulmonary surfactant is primarily composed of phosphatidylcholine
(PC) in complex with specialized surfactant proteins and secreted by alveolar type 2 (AT2)
cells. Surfactant homeostasis on the alveolar surface is balanced by the rates of synthesis …
