[HTML][HTML] Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with …
M Tanno, A Kuno, S Ishikawa, T Miki, H Kouzu… - Journal of Biological …, 2014 - ASBMB
Glycogen synthase kinase-3β (GSK-3β) is a major positive regulator of the mitochondrial
permeability transition pore (mPTP), a principle trigger of cell death, under the condition of
oxidative stress. However, the mechanism by which cytosolic GSK-3β translocates to
mitochondria, promoting mPTP opening, remains unclear. Here we addressed this issue by
analyses of the effect of site-directed mutations in GSK-3β on mitochondrial translocation
and protein/protein interactions upon oxidative stress. H9c2 cardiomyoblasts were …
permeability transition pore (mPTP), a principle trigger of cell death, under the condition of
oxidative stress. However, the mechanism by which cytosolic GSK-3β translocates to
mitochondria, promoting mPTP opening, remains unclear. Here we addressed this issue by
analyses of the effect of site-directed mutations in GSK-3β on mitochondrial translocation
and protein/protein interactions upon oxidative stress. H9c2 cardiomyoblasts were …